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| Authors | M.L. Ciavatta, M.P. Lopez Gresa, M. Gravagnin, V. Romero, D. Melck, E. Manzo, Y.W. Guo, R.W.M. van Soest, G. Gimino | | Title | Studies on puupehenone-metabolites of a Dysidea sp.: structure and biological activity. |
| Journal | Tetrahedron |
| Volume | 63 |
| Year | 2007 |
| Pages | 1380-1384 |
| ISSN | 00404020 |
| Faculty | Faculty of Science |
| Institute/dept. | FNWI: Zoological Museum Amsterdam (ZMA) |
| Keywords | Marine metabolites; Sponges |
| Abstract | Abstract—Puupehenone (1) and a series of its congeners (2–6) have been isolated from a Dysidea sponge. The unprecedented 20-acetoxyhaterumadienone (2) exhibiting a five-membered contracted ring, has been characterized. In addition, stereochemical assignment of two previously reported acetone adducts of puupehenone (5 and 6) has been made. Finally, the inhibition of mitochondrial respiratory chain as well as antibacterial and antifungal activities of all compounds has been evaluated. |
| Document type | Article |
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