Pharmacological and physiological functions of polyspecific drug transporters

Authors	J.W. Jonker
Supervisors	P. Borst
Cosupervisors	A.H. Schinkel
Award date	12-09-2003
ISBN	9064646899 9789064646898
Number of pages	123
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: GEMO
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview Chapter 2 Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug Chapter 3 Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan Chapter 4 The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria Chapter 5 Pharmacological and physiological functions of the polyspecific organic cation transporters OCT1, 2 and 3 (SLC22A1-3) Chapter 6 Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) gene Chapter 7 Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations Summary & Samenvatting Dankwoord Curriculum vitae List of publications Abbreviations Cover
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