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| Authors | G. Carr, M. Raszek, R.W.M. van Soest, T. Matainaho, M. Shopik, C.F.B. Holmes, R.J. Andersen | | Title | Protein Phosphatase Inhibitors Isolated from Spongia irregularis Collected in Papua New Guinea |
| Journal | Journal of natural products |
| Volume | 70 |
| Year | 2007 |
| Pages | 1812-1815 |
| ISSN | 01633864 |
| Faculty | Faculty of Science |
| Institute/dept. | FNWI: Zoological Museum Amsterdam (ZMA) |
| Keywords | ...; ... |
| Abstract | Irregularasulfate (1), a new nitrogen-containing sesterterpenoid, and the known sesterterpenoids hipposulfate C (2),halisulfate-7 (3), and igernellin (4), have been isolated from the marine sponge Spongia irregularis collected in Papua New Guinea. The structure of 1 was elucidated via analysis of its spectroscopic data. Sesterterpenoids 1, 2, and 3 are moderate inhibitors of the catalytic subunits of the mammalian Ser/Thr protein phosphatases calcineurin, PP-1, and
PP-2A. The phosphate analogue of 3 and the thiophosphate analogue of 2 have been prepared from the corresponding natural products and evaluated for their ability to inhibit the phosphatase activity of calcineurin. |
| Document type | Article |
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