Zoekresultaten

Zoekopdracht: faculteit: "FNWI" en publicatiejaar: "2011"

AuteurPaula Vieweg
TitelHippocampal pattern separation and completion in humans
BegeleidersThomas Wolbers, Cyriel M.A. Pennartz
Jaar2011
FaculteitFaculteit der Natuurwetenschappen, Wiskunde en Informatica
OpleidingFNWI MSc Brain and Cognitive Sciences
SamenvattingThis study has investigated the two processes pattern separation and completion, which are essential in memory formation and decoding as to overcome interference. With a focus on the hippocampal subregions CA1 and CA3, a virtual environment was implemented, and its spatial configuration was gradually altered up to a completely different scene. Participants performed an unrelated encoding task while situated in an fMRI scanner. High-resolution imaging data was objected to multivariate pattern analysis by means of correlations of activity between original and altered scenes. Identical step functions for CA1, CA3 and DG were observed, suggesting that the human hippocampus picks up already small changes. Subject's reports render this process unconscious. Limitations and possible objections are discussed and suggestions for further research are given. 2
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