Zoekresultaten

Zoekopdracht: faculteit: "FNWI" en publicatiejaar: "2009"

AuteurBjörn van der Hoort
TitelPartial NMDA-antagonist dextromethorphan disrupts recurrent processing
BegeleidersAnouk van Loon, Steven Scholte, Victor Lamme
Jaar2009
FaculteitFaculteit der Natuurwetenschappen, Wiskunde en Informatica
OpleidingFNWI MSc Brain and Cognitive Sciences
SamenvattingRecurrent processing is necessary for visual awareness in contrast to feedforward processing. We tried to explain these differences between recurrent processing and feedforward processing on a neuronal level by investigating the influence of a partial NMDA-antagonist (120 mg dextromethorphan) on these two different processes. Subjects performed a masked scene segmentation task similar to Fahrenfort et al. (2007). We partially replicated his findings. Recurrent processing was disrupted by masking. However, in contrast to the findings of Fahrenfort we also found that feedforward processing was disrupted by masking. In addition to the study by Fahrenfort we varied the intensity of the masks. Intermediate mask intensities yield intermediate amounts of recurrent processing and intermediate visibility of target stimuli. Dextromethorphan disrupted the visibility of masked stimuli (slightly) and recurrent processing (more pronounced). These results indicate an elementary role of NMDA-receptor activation in recurrent processing and visual awareness.
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