The role of the phosphatase Pten in T cell development

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Query: faculty: "AMC-UvA" and publication year: "2008"

Author	T.J. Hagenbeek
Title	The role of the phosphatase Pten in T cell development
Promotor	H. Spits
Date	13-05-2008
Year	2008
Pages	178
Faculty	AMC-UvA
Keywords	T-lymphocytes; Development (process); Phosphatases
Classification	44.45 immunology (medicine)
Language	English
Document type	Dissertation
Download papers	Thesis Cover Titlepage Contents Chapter 1 General introduction: Normal and malignant T cell development: the role of PI3K and Notch Chapter 2 The loss of PTEN allows TCR αβ lineage thymocytes to bypass IL-7 and pre-TCR mediated signaling Chapter 3 Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking Chapter 4 T cell lymphomas in T cell-specific Pten-deficient mice originate in the thymus Chapter 5 TCR signaling is required for thymic exit of healthy and malignant Pten-deficient thymocytes Chapter 6 Malignant Pten-deficient thymocytes utilize independent PI3K- and Notch1-mediated signaling for survival and proliferation, and acquire activating NOTCH1 mutations upon loss of γc- and/or (pre-)TCR-mediated signaling Chapter 7 General discussion Summary Samenvatting List of publications Curriculum Vitae Dankwoord Stellingen
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