β2-glycoprotein I in innate immunity

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Query: faculty: "AMC-UvA" and publication year: "2011"

Author	Ç. Ağar
Title	β2-glycoprotein I in innate immunity
Promotors	J.C.M. Meijers, P.G. de Groot
Date	15-09-2011
Year	2011
Pages	138
Faculty	AMC-UvA
Keywords	β2 GPI; APS; LPS; conformation; antiphospholipid; antibodies
Abstract	Het antifosfolipidensyndroom wordt gekenmerkt door de aanwezigheid van antistoffen tegen het eiwit β2-glycoproteine I. Herkenning van het eiwit door de antistof vindt alleen plaats onder bepaalde omstandigheden. Dit is van belang voor de diagnose van het antifosfolipidensyndroom. Çetin Ağar beschrijft, veertig jaar na de ontdekking van het eiwit, voor het eerst de functie ervan: het speelt een beschermende rol in het immuunsysteem door het wegvangen van ontstekingsmediatoren gemaakt door bacteriën.
Language	English
Document type	Dissertation
Download papers	Thesis Cover Title pages Contents Chapter 1: General introduction Chapter 2: β2-Glycoprotein I is incorrectly named apolipoprotein H Chapter 3: β2-Glycoprotein I can exist in two conformations: implications for our understanding of the antiphospholipid syndrome Chapter 4: β2-Glycoprotein I: a novel protein in innate immunity Chapter 5: Evolutionary conservation of the LPS binding site of β2-Glycoprotein I Chapter 6: Induction of auto-antibodies against β2GPI in mice by protein H of streptococcus pyogenes Chapter 7: Summary & discussion Chapter 8: Nederlandse samenvatting Dankwoord List of publications
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