The UvA-LINKER will give you a range of other options to find the full text of a publication (including a direct link to the full-text if it is located on another database on the internet).
De UvA-LINKER biedt mogelijkheden om een publicatie elders te vinden (inclusief een directe link naar de publicatie online als deze beschikbaar is in een database op het internet).

Zoekresultaten

Zoekopdracht: journal id: "physicalxreviewxletters"

AuteursR. Ni, S. Abeln, M. Schor, M.A. Cohen Stuart, P.G. Bolhuis
TitelInterplay between Folding and Assembly of Fibril-Forming Polypeptides
TijdschriftPhysical Review Letters
Jaargang111
Jaar2013
Nummer5
ISSN00319007
FaculteitFaculteit der Natuurwetenschappen, Wiskunde en Informatica
Instituut/afd.FNWI: Van 't Hoff Institute for Molecular Sciences (HIMS)
SamenvattingPolypeptides can self-assemble into hierarchically organized fibrils consisting of a stack of individually folded polypeptides driven together by hydrophobic interaction. Using a coarse-grained model, we systematically studied this self-assembly as a function of temperature and hydrophobicity of the residues on the outside of the building block. We find the self-assembly can occur via two different pathways-a random aggregation-folding route and a templated-folding process-thus indicating a strong coupling between folding and assembly. The simulation results can explain experimental evidence that assembly through stacking of folded building blocks is rarely observed, at the experimental concentrations. The model thus provides a generic picture of hierarchical fibril formation.
Soort documentArtikel
Download
Document finderUvA-Linker