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Zoekopdracht: faculteit: "FNWI" en publicatiejaar: "2012"

AuteurP.G. Meirmans
TitelThe trouble with isolation by distance
TijdschriftMolecular Ecology
Jaargang21
Jaar2012
Nummer12
Pagina's2839-2846
ISSN09621083
FaculteitFaculteit der Natuurwetenschappen, Wiskunde en Informatica
Instituut/afd.FNWI: Institute for Biodiversity and Ecosystem Dynamics (IBED)
SamenvattingThe genetic population structure of many species is char- acterised by a pattern of isolation by distance (IBD): due to limited dispersal, individuals that are geographically close tend to be genetically more similar than individuals that are far apart. Despite the ubiquity of IBD in nature, many commonly used statistical tests are based on a null model that is completely non-spatial, the Island model. Here, I argue that patterns of spatial autocorrelation deriving from IBD present a problem for such tests as it can severely bias their outcome. I use simulated data to illustrate this problem for two widely used types of tests: tests of hierarchical population structure and the detec- tion of loci under selection. My results show that for both types of tests the presence of IBD can indeed lead to a large number of false positives. I therefore argue that all analyses in a study should take the spatial depen- dence in the data into account, unless it can be shown that there is no spatial autocorrelation in the allele fre- quency distribution that is under investigation. Thus, it is urgent to develop additional statistical approaches that are based on a spatially explicit null model instead of the non-spatial Island model.
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