The UvA-LINKER will give you a range of other options to find the full text of a publication (including a direct link to the full-text if it is located on another database on the internet).
De UvA-LINKER biedt mogelijkheden om een publicatie elders te vinden (inclusief een directe link naar de publicatie online als deze beschikbaar is in een database op het internet).

Zoekresultaten

Zoekopdracht: faculteit: "FNWI" en publicatiejaar: "2010"

AuteursA. Huerta-Viga, D.J. Shaw, S. Woutersen
TitelpH dependence of the conformation of small peptides investigated with two-dimensional vibrational spectroscopy
TijdschriftThe journal of physical chemistry. B
Jaargang114
Jaar2010
Nummer46
Pagina's15212-15220
ISSN15206106
FaculteitFaculteit der Natuurwetenschappen, Wiskunde en Informatica
Instituut/afd.FNWI: Van 't Hoff Institute for Molecular Sciences (HIMS)
SamenvattingWe investigate how the conformation of small peptides is influenced by the presence or absence of charge on the C-terminus and on the side groups. To this purpose, the conformations of two tripeptides, with acidic and basic side groups, is determined at several pD values using two-dimensional infrared (2DIR) spectroscopy. The investigated pD values are chosen relative to the C-terminal and side-chain pKa values in such a way that the C-terminus and side groups are in well-defined protonation states. The measurements are analyzed quantitatively using an excitonic model for the Amide I′ mode. From the vibrational coupling and the angle between the Amide I′ transition dipoles obtained in this way, the dihedral angles (φ,ψ) of the central Cα atom are determined. Interestingly, our measurements show that the backbone structure of the peptides is remarkably stable against changing the charges of both the side groups and the C-terminal carboxylate groups. This is probably a consequence of effective screening of the Coulomb interactions between the charged groups by the water molecules between them. We also find that the (φ,ψ) confidence regions obtained from 2DIR measurements can have highly irregular shapes as a consequence of the nonlinear relation between the dihedral angles and the experimentally determined Amide I′ coupling and transition-dipole angle.
Soort documentArtikel
Document finderUvA-Linker