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Zoekresultaten

Zoekopdracht: faculteit: "FMG" en publicatiejaar: "2011"

AuteursA.O.J. Cramer, K.S. Kendler, D. Borsboom
TitelWhere are the genes? The implications of a network perspective on gene hunting in psychopathology. [A commentary on Johnson et al.].
TijdschriftEuropean Journal of Personality
Jaargang25
Jaar2011
Nummer4
Pagina's270-271
ISSN08902070
FaculteitFaculteit der Maatschappij- en Gedragswetenschappen
Instituut/afd.FMG: Psychology Research Institute
SamenvattingThe missing heritability problem is pervasive and Johnson, Penke and Spinath (2011) present a number of compelling reasons for its existence. In this comment, we present another reason for the apparent discrepancy between heritability estimates and gene‐hunting results in psychopathological research: if syndromes are networks of causally related symptoms in which both symptoms and relations between them are driven by different sets of genetic polymorphisms, then gene hunting based on a phenotypic sumscore might be ill‐advised because it will only capture genetic variance shared among those symptoms and their relations.
OpmerkingenDiscussion on 'Heritability in the era of molecular genetics: some thoughts for understanding genetic influences on behavioural traits' Wendy Johnson, Lars Penke, and Frank M. Spinath: open peer commentary.
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