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Zoekopdracht: faculteit: "FMG" en publicatiejaar: "2002"

AuteursJ.M.J. Murre, M. Meeter, L.M. Talamini
TitelA computational approach to memory deficits in schizophrenia
TijdschriftNeurocomputing: An International Journal
Jaargang46
Jaar2002
Nummerjune
Pagina's929-936
FaculteitFaculteit der Maatschappij- en Gedragswetenschappen
Instituut/afd.FMG: Psychology Research Institute
TrefwoordenHippocampus; Temporal-Lobe; Schizophrenia; Mathematical-Modeling; Episodic-Memory
SamenvattingEpisodic memory impairment is one of the most reliable neuropsychological findings in schizophrenia. It has been suggested that medial temporal lobe abnormalities in schizophrenia underlie this impairment. This article suggests that the specific memory deficits in schizophrenia may be caused by abnormal hippocampo-cortical communication via parahippocampal areas. The researchers used connectionist simulations to investigate this notion. Simulations involved list learning in a model that incorporates characteristics of the hippocampal and parahippocampal region. In this model context was used to store and recall episodic memories. Reduction of the nodes in the parahippocampal module of the model resulted in a schizophrenia-like memory deficit profile.
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