Zoekopdracht:
faculteit: "ACTA" en publicatiejaar: "2010"
| Auteurs | R.A. Mendes, J.F.C. Carvalho, I. van der Waal | | Titel | Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment - An overview |
| Tijdschrift | Oral Oncology |
| Jaargang | 46 |
| Jaar | 2010 |
| Nummer | 1 |
| Pagina's | 19-24 |
| ISSN | 13688375 |
| Faculteit | ACTA |
| Samenvatting | In the classification of Head and Neck Tumors, published in 2005 by the World Health Organization Classification, the odontogenic keratocyst has been reclassified as a benign intraosseous neoplasm, calling it “keratocystic odontogenic tumor” (KCOT).
Significant differences on the molecular level between KCOT and other odontogenic cystic lesions suggest a different biological origin. Genetic and molecular research regarding odontogenic tumors, and KCOTs in particular, has led to an increasing amount of knowledge and understanding of their physiopathological pathways.
A review of the biological behavior of this recognized aggressive pathological entity of the jaws and a contemporary outline of the molecular (growth factors, p53, PCNA and Ki-67, bcl-2) and genetic (PTCH, SHH) alterations associated with this odontogenic neoplasm provides a better understanding of the mechanisms involved in its development and strengthen the current concept that the KCOT should, indeed, be regarded as a neoplasm.
Furthermore, markers known to be rapidly induced in response to growth factors, tumor promoters, cytokines, bacterial endotoxins, oncogenes, hormones and shear stress, such as COX-2, may also shed new light on the biological mechanisms involved in the development of these benign but sometimes aggressive neoplasms of the jaws. |
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