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Zoekopdracht: faculteit: "ACTA" en publicatiejaar: "2009"

AuteursA.L.J.J. Bronckers, D.M. Lyaruu, I.D.C. Jansen, J.F. Medina, S. Kellokumpu, K.A. Hoeben, L.R. Gawenis, R.P.J. Oude Elferink, V. Everts
TitelLocalization and function of the anion exchanger Ae2 in developing teeth and orofacial bone in rodents
TijdschriftJournal of Experimental Zoology. Part B Molecular and Development Evolution
SamenvattingTo explore the functions of the anion exchanger 2 (Ae2) in the development of bones and teeth we examined the distribution of Ae2 in cells involved in the formation of teeth and surrounding bone in young hamsters, mice and rats. In all three species strongest immunostaining for Ae2 was obtained in basolateral membranes of maturation ameloblasts and in osteoclasts resorbing bone. In hamsters a weaker staining was also seen in the Golgi apparatus of secretory ameloblasts, young osteoblasts and osteocytes, odontoblasts and fibroblasts of the forming periodontal ligament. In adult Ae2math image mice, in which Ae2-targeted disruption precluded the expression of Ae2a, Ae2b1 and Ae2b2 isoforms, the immunostaining for Ae2 in ameloblasts and osteoclasts was totally abolished. The enamel formation was abnormal but teeth erupted, osteoclasts in jaw bone were functional and structure of dentin and bone was normal. In another mouse model, Ae2−/− mice in which the expression of all five Ae2 isoforms was disrupted, teeth failed to erupt and the alveolar bone proved poorly formed with giant but apparently functional osteoclasts. Our data indicate that basolaterally located Ae2a, Ae2b1 or Ae2b2 (or a combination of these) is present in maturation ameloblasts critical for the cells' normal functioning. Although isoforms of Ae2 were also present in basolateral membranes of osteoclasts, they proved to be not critical to osteoclast resorption of orofacial bone. Poorly formed bone and the failure of teeth to erupt seen in the Ae2−/− mice with gene disruption affecting all isoforms may result from secondary (systemic) changes that are different from Ae2math image mice.
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