The UvA-LINKER will give you a range of other options to find the full text of a publication (including a direct link to the full-text if it is located on another database on the internet).
De UvA-LINKER biedt mogelijkheden om een publicatie elders te vinden (inclusief een directe link naar de publicatie online als deze beschikbaar is in een database op het internet).

Search results

Query: institute/department: "FNWI: Institute for Biodiversity and Ecosystem Dynamics IBED" and publication year: "2008"

AuthorsM.M. Leijs, J.G. Koppe, K. Olie, W.M.C. van Aalderen, P. de Voogt, T. Vulsma, M. Westra, G.W. ten Tusscher
TitleDelayed initiation of breast development in girls with higher prenatal dioxin exposure: A longitudinal cohort study
JournalChemosphere
Volume73
Year2008
Issue6
Pages999-1004
ISSN00456535
FacultyFaculty of Science
AMC-UvA
Institute/dept.FNWI: Institute for Biodiversity and Ecosystem Dynamics (IBED)
AbstractObjectives: While many studies have assessed the health impacts of PCDD/Fs and PCBs on animals and humans, long-term consequences for especially adolescents, have not (yet) been well documented. This is certainly also true for the effects of PBDE exposure. As part of a longitudinal cohort study, now well into its second decade, effects of perinatal and current PCDD/F exposure, as well as current dl-PCB and PBDE exposures, on puberty, were assessed. Study design: Prenatal, lactational and current PCDD/F, dl-PCB and PBDE concentrations were determined using GC–MS. Pubertal development and growth were assessed by means of physical examination and the Tanner scale. 33 Children (born between 1986 and 1991) consented to the current follow-up study. Outcomes were evaluated using linear regression or the non parametric Spearman's correlation coefficient. Results: A delay in initiation of breast development was found in girls (n = 18) with higher prenatal (p = 0.023) and lactational PCDD/F exposure (p = 0.048). The males revealed a negative trend with age at first ejaculation. For other endpoints on puberty and growth (pubic hair, axillary hair, genital stage, length, BMI, testicular volume, menarche) no significant relation was found with any of the measured compounds. Discussion and conclusion: A relation between prenatal PCDD/F exposure and later initiation of breast development was seen. A Belgian study found a delay in breast development with higher current serum concentrations of dioxin-like compounds. The initiation of puberty is a complex process and it is yet not clear how dioxin-like compounds precisely affect this process prenatally. Further follow-up into adulthood is warranted, in order to detect the possibility of developing malignancies and fertility problems.
Document typeArticle
Document finderUvA-Linker