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faculty: "FNWI" and publication year: "2010"
| Authors | J. Kalkman, R. Sprik, T.G. van Leeuwen | | Title | Path-length-resolved diffusive particle dynamics in spectral-domain optical coherence tomography |
| Journal | Physical Review Letters |
| Volume | 105 |
| Year | 2010 |
| Issue | 19 |
| Pages | 198302- |
| ISSN | 00319007 |
| Faculty | Faculty of Science
AMC-UvA |
| Institute/dept. | FNWI: Van der Waals-Zeeman Institute (WZI) |
| Abstract | We describe a new method to measure the decorrelation rate of the optical coherence tomography (OCT) magnitude simultaneously in space and time. We measure the decorrelation rate of the OCT magnitude in a Fourier-domain OCT system for a large range of translational diffusion coefficients by varying the sphere diameter. The described method uses the sensitivity advantage of Fourier-domain OCT over time-domain OCT to increase the particle diffusion imaging speed by a factor of 200. By coherent gating, we reduce the contribution of multiple scattering to the detected signal, allowing a quantitative study of diffusive particle dynamics in high concentration samples. We demonstrate that this technique is well suited to image diffusive particle dynamics in samples with a complex geometry as we measure the morphology and diffusive particle dynamics simultaneously with both high spatial and high temporal resolution. |
| Document type | Article |
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